Diabetic kidney damage (diabetic nephropathy) develops insidiously and screening is therefore important for early detection and treatment. Microalbuminuria (20-300 mg/L), which means that the kidney leaks small amounts of albumin into the urine, is the first clinical sign of kidney damage. The progression of kidney damage increase the level of albuminuria giving macroalbuminuria (>300 mg/L) and increasing renal impairment. End-stage kidney disease is the complete or almost complete failure of the kidneys to function. The kidneys can no longer remove wastes, concentrate urine, and regulate many other important body functions. If the kidneys fail to function dialysis or kidney transplantation might be the only treatment. By achieving good blood pressure and blood glucose control and by the use of drugs including ACEI (Angiotensin- Converting Enzyme Inhibitors) and ARB (Angiotensin Receptor Blockers) it is possible to reduce and sometimes even reverse the development of diabetes nephropathy, which otherwise is a progressive disease.